ࡱ> 6  !"#$%&'()*+,-7/012345>89:;<=?@ARoot Entry F@7IW@SummaryInformation(DocumentSummaryInformation8WordDocument3\  Oh+'0 $ 8 D P \hpx2018t^^)Y%m^yf[b/gVYc TyvkatyNormal861508@@S/6O@Z@vHW Microsoft Office Word ՜.+,D՜.+,HPXt|  Microsoft $ 0t|KSOProductBuildVerICV2052-11.1.0.13703!0C2AF002C4AA4FCE9D3BE2416E1B3ED00Table.{Data WpsCustomData P/KSKS3\   \ \  yj$h`q d 2022t^^SN^yf[b/gVYc Tyv lQ:yW,g`Qh yv Ty Ny͑ue:g6Reh_irNeRʋeb/gSV{euvxvzN^(uc TVYyTI{~VYySNyf[b/gۏekVY I{~ NI{VY;N[bUSMO10-NVNl>eQ;`;Sb;20SN'Yf[;30-NVyf[b_uirxvz@b;40lS;Sy'Yf[,{ N;Sb;50e!wmeQ\;Sf[b/g gPlQS;N [bN10uofl;20Ql;30_[N;40WSgOe;50ёNS;60sz~t;70Hh;80Yf;90Hz;100Rh~;110=NZ;120sys;130u }$;140f_O;150hg9N=Nc TUSMO-NVNl>eQ;`;Sbc TabV/fu'YV ba'`YNWpCHB 0^R|'`'`uNAFLD S bWpHE qS[%N͑ MNO~+gguvSusT{kNsR[s[uuhQ zvKm0|QʋeT gHelu0 ,gyvSe21t^ (WV[yb͑'YNy0973I{38y/ec N (W Ny͑uCHB0NAFLD0HE sQ.:g6R0eh_irNeNNeRʋeb/gSV{euvxvzN^(uebS_͑'Yz4x >fWcRNbV͑u4N^ʋub/g4ls^0She166{ q_TVP[633R (WLancetI{IF>10Rg R NShe14{ N_3852!k VEN[ċ14{ ;NNW40bg~eQu2lcWSbqQƋ70NMPA0'kvCESVFDANTT1y bVSVEN)R52y oNW\OCg9y0bglSSNNS (W0W:SI{hQV900YO[;Sb^l^(u 4N^0>yOHevASR>fW я Nt^~NmHevя$NNCQ0 yvb/gRe z^_ؚ b/g^_'Y lS0NNSS4N^c^^(u^l ;`SO4ls^0RVEHQbHQۏ0 TacP3ubSN^ybۏekNI{VY0yv{NbV/fu'YV vQ-Nba'`HBVagN7300N ba'`YNWpCHB `>2000N0яNASt^eg ^ag'`uHT>fW NGS`R bV^R|'`'`uNAFLD Sus15% - 25% NAFLDN>2N SN0W:S^\ NAFLD ؚAmL:S0 bWpukHEV agHT@\AmLTceS hQtkt^~2000NNagHEV kt^{kNuO~5N bWpHE E\bV%`'`uk'`pMO ba'`ùof`HEVagf͑uS MQuRb6RbNO NNagHEV gSba'`S0ba'`p  ~~S  lxS  ~ހLv/f;Nba'`uuuۏU\v Vf kt^{kNHBVag@bv1YNPlxS0LvSpz~+ggu~35NN >20%v^R|'`'`pNASH SۏU\:NlxSCN󁝀~ހLv qS[%N͑0[ Ny͑uCHB0NAFLD0HE SuNۏU\v͑:g6R\*g[hQfs gʋeTċNb/g0h_irSch:ONbX[(W@\P'` N[sNSuRY~+gguT4N^sQ.6kvhQ zR`vKm0ʋeSTċ0OWNeRʋeh_Tb/g/edv4N^ʋuV{eu_[U0:Ndk MNOvsQ~+gguvSusTu{ksR4xvsQ͑'Y4N^W@x [~beWeRʋeTc[4N^luh_ir0xSeWeRʋeb/g N [s[uuۏU\vhQ zvKmT|Qr^;e0 ,gyvSe21t^ (WV[ ASNN 0 ASNN yb͑'YNy097308630Q͑'Y4N^ؚeb/gyvI{38yWё/ec N xvzN Ny͑uSuNۏU\ve:g6R |~[{ N@nf[eRʋeTc[4N^luveWh_ir xSN|R͑ueRʋeeb/gv^4N^^llS^(u ƖbR^N Ny͑uteTeRhKmeV{eu bg^lc^^(u :NbV͑uv2ccONsQ.b/gT͑t/ed 4N^0>yOS~NmHevASR>fW0bgShe166{ vQ-NSCIe106{ q_TVP[633R (WLancet0Gastroenterology0Hepatology0J HepatolI{IF&gt;10Rg R NShe14{ N_3852!k0(WNature Immunology0Hepatology0J HepatolI{SCIg RVEN[ċ14{ ;NNW4 AASLDI{VEObJTbeNAm37{0bg~eQVQY͑u2lcWSbN[qQƋ70NMPA0'kvCESVFDANTT1y bVSVEb/gSfN)R35y [(ueWSY‰N)R17y oNW\OCg9y0bg4N^lSSNNS (WShQVvQ[0W:S900[;Sb^l^(u 4N^0>yOHevASR>fW я Nt^Nuvc~NmHev19860NCQ0Ssp/Sfp/Rep1. VE N!kSs8hx {|oirluHBV DNA b6RTl:NNHBV RNA:N;Nv Y6R:wW!j_ eEQ[UN~xQHBV Y6R!j_ cQNuk-[;NRNAcvhRNA zNQ~f[sHQt[Ngp96ؚHe[HBVyr_'`CTLMQu^T{fnxNAFPOHCCvRP[c:g6RSsNGT4 HEVba'`SncSMQu:g6R :NvsQu2lcONev͑yf[Onc0 2. sHQ[HBV RNA0HBcrAg/fc[CHBbukluveWh_irSsGP730FGF-210PEDFI{N~~~S/lxS@nʋeeh_ir!k^zNS`[(uvHBV cccDNA0HBV RNA[ϑhKm0eWY͑oS_hKmI{|Rb/gSsNN~S(uNHCCʋeST$RevmiRNAsSDNA2uWSMOp24*N 4N^^(u>fWcGSNvsQuʋlv|Q'`N gHe'`0 3. xSNeNN~~SeRʋeeb/gSNTFibroTouch V[;SuhVhlQS'kvCE 4N^^l^(u>fWQ\N~~SʋeSvKm-Nz gRuthgvO(u 4N^0>yOHevASR>fW0 4. WNeWh_irSs0sQ.b/gReSlS^(u ƖbR^N͑u6h_teTeRhKmeV{eu 4N^c^^(ubHe>fW0;Nb/g/edPgeNh'`e [1] Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound Jie Wang, Tao Shen, Xiangbo Huang, G. Renuka Kumar, Xiangmei Chen, Zhenzhen Zeng,Ruiyang Zhang, Ran Chen, Tong Li, Tianying Zhang, Quan Yuan, Pao-Chen Li, Qi Huang,Richard Colonno,Jidong Jia,Jinlin Hou,Malcolm A. McCrae,Zhiliang Gao,Hong Ren,Ningshao Xia,Hui Zhuang, Fengmin Lu,Journal of Hepatology 2016, 65(4):700-710. [2] HBV-specific peptide associated with heat-shock protein gp96 Song-Dong Meng, Tong Gao, George F Gao, Po Tien Lancet 2001, 357(9255):528-529. [3] Hepatitis E virus infection in acute non-traumatic neuropathy: A large prospective case-control study in China. Wang, Yijin; Wang, Shan; Wu, Jian; Jiang, Yiyun; Zhang, Haiying; Li, Shujuan; Liu, Hongyang; Yang, Changshuang; Tang, Haijun; Guo, Naizhou; Peppelenbosch, Maikel P.; Wei, Lai; Pan, Qiuwei; Zhao, Jingmin. Lancet EBIOMEDICINE, 2018, 53(36): 122-130. [4] Hepatitis B Virus Virions Produced Under Nucleostide Analogue Treatment Are Mainly Not Infectious Because of Irreversible DNA Chain Termination Yongzhen Liu,Hui Liu,Zhanying Hu,Yang Ding,Xiao-Ben Pan, Jun Zou,Jingyuan Xi,Guangxin Yu,Hongxin Huang,Meng-Ting Luo,Fang Guo,Shuang Liu,Qiuju Sheng,Jidong Jia,Yong-Tang Zheng,Jie Wang, Xiangmei Chen, Ju-Tao Guo Lai Wei,and Fengmin Lu Hepatolog 2020;71(2):463-476. [5] Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity Saifeng Wang,Lipeng Qiu,Xiaoli Yan,Wensong Jin,Yanzhong Wang,Lizhao Chen,Erjie Wu, Xin Ye,George F. Gao,1 Fusheng Wang,Yu Chen,Zhongping Duan,and Songdong Meng Hepatology 2012, 55(3):730-741. wƋNCgThQĉ O] Yf s8l\ ^YwZ ck3 4 b/gSfN)RNyؚupOe^Tyr_v@mHBV pgRNAgIQ[ϑPCRhKmSO|ThKmel ZL201710213191.3 Cg)RNSN'Yf[ SfNQl spg H6q 5 b/gSfN)RGP73ve(uSNyWNvQv~~pu;mR^hKmՋBRv ZL201710289636.6 Cg)RNQl Yf SfNQl Yf 6 b/gSfN)RvKmw!SW~~YNWpukcccDNAvՋBRv ZL201010237282.9 Cg)RN-NVNl>eQ,{ N0N;Sb SfNf_O _Ns^ sO*t uofl ckGS ςUOs NSf:_ Rh~ 7 b/gSfN)RnsibXR:SgIQ[ϑPCRhKmYNWpukcccDNAՋBRv ZL201010237281.4 Cg)RN-NVNl>eQ,{ N0N;Sb SfNf_O _Ns^ sO*t uofl ckGS ςUOs NSf:_ Rh~ 8 b/gSfN)RNpOKQˆ}vgp96(W6RY[{guvNT-Nv^(u ZL 201410535528.9 Cg)RN-NVyf[b_uirxvz@b SfN_[N OQY Bhff ub Hz 9 b/gSfN)RWNXlv[ϑelS|~ ZL201510306622.1 Cg)RNe!wmeQ\;Sf[b/g gPlQS SfNёNS Y[& kT)R 10 b/gSfN)R~~9_'`bPelTVb_YthV ZL201510790828.6 Cg)RNe!wmeQ\;Sf[b/g gPlQS SfNSf ёNS Y[& kT)R  $&46>@z~F J ƻxplhd^XPHEACJo(CJCJ^Jo(aJCJ^Jo(aJ CJ^Jo( CJ^Jo(CJo(CJo(CJo(CJ^Jo(aJCJ^Jo(aJCJ^Jo(aJCJaJ mHsHnHtHCJ^Jo(aJCJ^Jo(aJCJ,OJPJQJaJ,CJ,OJPJQJaJ,CJ,OJPJQJaJ,CJ,OJPJQJaJ,CJ,OJPJQJo(aJ,CJ,OJPJQJaJ,CJ,OJPJQJo(aJ,CJ,OJPJQJaJ,J N P V X    " $ 8 < D F d    0 8   D F Žytni[VQCJaJCJaJCJo(aJmH sH nHtHCJaJ CJo(aJCJaJ CJo(aJCJaJ CJo(aJCJaJ CJo(aJCJaJCJaJ CJo(aJCJ^Jo(aJCJ^Jo(aJCJo(CJo(CJ^Jo(aJCJ^Jo(aJCJo(CJo(CJCJo(CJCJ^Jo(aJCJ^Jo(aJCJ^Jo(aJCJ^Jo(aJF DFP~BD¼|wrmhbZRCJ^Jo(aJCJ^Jo(aJ ^Jo(aJ^JaJ^JaJ^JaJ^JaJ^JaJ^JaJ^JaJCJ^Jo(aJCJ^Jo(aJ ^Jo(aJ^JaJ ^Jo(aJ^JaJ ^Jo(aJ^JaJ ^Jo(aJ^JaJ ^Jo(aJ^JaJ ^Jo(aJ^JaJ ^Jo(aJCJ^Jo(aJCJ^Jo(aJ CJo(aJ CJo(aJ:<bdfhlnFHTV|qh]TI@5B*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJ(B*phPJ^Jo(aJmH sH nHtH$B*ph^Jo(aJmH sH nHtHB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^Jo(aJV  !!!! ""\"^"`"b"úvkbO:/B*ph^Jo(aJ(B*phPJ^Jo(aJmH sH nHtH$B*ph^Jo(aJmH sH nHtHB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^JaJB*ph^JaJB*ph^JaJB*ph^Jo(aJ(B*phPJ^Jo(aJmH sH nHtH$B*ph^Jo(aJmH sH nHtHB*ph^JaJb"##.%0%p%r%%%%%&&((((@(B(ú~sj_VKB/$B*ph^Jo(aJmH sH nHtHB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJ(B*phPJ^Jo(aJmH sH nHtH$B*ph^Jo(aJmH sH nHtHB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB(D(V(X(((((()J)L)N)P)t)))))ɾwncZOF;B*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^Jo(aJB*ph^Jo(aJB*ph^Jo(aJB*ph^Jo(aJ(B*phPJ^Jo(aJmH sH nHtH)***D*f*p*x********+++<+X+j+|sh_TK@7B*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^Jo(aJj+l+n+p++++++++ , ,,, ,R,~,,,,ú~ujaVMB9B*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJ,,,,6-b-|------ ....8.N.X.|.~..øzqf]RI@5B*ph^Jo(aJB*ph^JaJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^Jo(aJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJ......////"/N/p/z//////ú|sh]RMOJQJCJ OJPJQJaJ B*ph^Jo(aJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJB*ph^Jo(aJB*ph^JaJ&6@|~G; d4a$$$If$$If:V 44l44l0$0$55d4WDd`$If d4a$$$If a$$G$ @ a$$G$ @ H aUL d4$If d4a$$$If$$If:V 44l44l0W$0$55 d4a$$$If d4$IfH J P X  vj^U d4$If d4a$$$If d4a$$$If$$If:V 44l44l0W$0$55  $ : vja d4$If d4a$$$If$$If:V 44l44l0W$0$55: < F F vjaXO d4$If d4$If d4$If d4a$$$If$$If:V 44l44l0W$0$55p(p(^0`0o( H^H\`\)^\`\.^\`\.4^4\`\) ^ \`\.| ^| \`\. ^ \`\)^\`\.p(&66666666666666668 0@P`6(666(88 0@P`p 0@P`p 0@P`p 0@P`p 0@P`pR@Rcke a$$1$(CJOJQJaJKHmH sH nHtH_HN@Nh 1dha$$$$@&CJ,PJaJ,KH,\L@Lh 2dh$$@&CJ OJPJQJaJ \F@Fh 3dh$$@&CJ PJaJ 5\$A@$؞k=W[SONi@Nnfh*('@(ybl_(uCJaJ<O<7h_1dhWD`CJ PJXOX i_rRh - :_eW[r 11WD`CJ OJPJQJ@@@ Rhk=WD`OJPJQJaJVOV fontstyle01(B*ph$ !CJOJQJo(aJ56\]J F Vb"B()j+,./ !"H  : D ,//#$%&'()*+,- G.[x @Times New Roman-([SOAD eck\h[{SO_oŖў3$ .[x @Arial- |8ўSOA4 N[_GB2312N[-|8I{~_ACaslonPro-SemiboldCambria-([SO2018t^^)Y%m^yf[b/gVYc Tyvkaty86150 Qh㤇{g  $!N!),.:;?]}    & 6"0000 0 0 00000 =@\]^ Fvj[LdhWD`$IfdhWD`$If d4a$$$If$$If:V 44l44l0W$0$55Dvj[L=dhWD`$IfdhWD`$IfdhWD`$If d4a$$$If$$If:V 44l44l0_$0$55Dfg[NB6 dha$$$If dha$$$If & Fdh$If d4a$$$If$$If:V 44l44l0$0$55dhWD`$If `"%D(X((L)**l+ ,t dhh^h$If dhh^h$If dhh^h$If dhh^h$If dhh^h$If dhh^h$If & Fdh$If dha$$$If dha$$$If dha$$$If dha$$$If ,,-~.///5$$If:V 44l44l0$0$55 dhh^h$If dhh^h$If dhh^h$If dhh^h$If dhh^h$If/// @ 1. A!#"$%S2P18([{  0 0 00000;[P)?'+2   R6 sTJrFVny  0 GB Oj w r" S x#O JOq#)>~'t4t^%%2\PQWV5 ky! "G#8%a%X'])t*+R+'+56+D}+60X30p>0v(2r2B?66 959ZR:t:=/?3?Q?nZ@OABB=DD8D6EBE fG:IAI KLb%LeuL)MbKMRMTNC.O(ERzRTdT( UHXdXaY\c/\^:`)?`5bcKd e6gygpHZ^pL&p5,d4MisKhy44,d+Hr@,FRa>(n9 j/?9(b2J9AXsGz\(  z0(  * 3 ?cname   commondata,<eyJoZGlkIjoiNDY4Y2MyZmIwMjcyYjM3NjZkNDY3NmQ1YjExYmEwZGUifQ==@